Comparative Genomics & Phylogenetic Analysis

Running comparative and phylogenetic Workflows in KBase

KBase’s comparative genomics and phylogenetic analysis tools enable researchers to understand evolutionary relationships between organisms and explore structural and functional variance across genomes. By integrating public datasets with user data and tools to search for sequence homology, explore gene orthology, and construct phylogenetic linkages between organisms, KBase provides an advanced and useful platform for comparative genomics research.

Narrative Tutorials

• Build a Gene Tree – guides the user through the process of building a gene tree for the "Sulfate Adenylyltransferase" (Sat) gene from Candidatus Desulforudis audaxviator MP104C

• Phylogenomics of Sulfate Reducing Clostridia - Tutorial - Part 1: Comparative Functional Assignment– guides the user through the process of whole-genome phylogeny, homology, and domain family functional profiling.

• Genome Analysis 2: Identifying Features of Interest in Genomes – shows how to build a workflow for searching and identifying features within your genomes

• (coming soon) Genome Analysis 3: Domain Annotation and Feature Profiling – guides users through annotating protein families and analyzing features across a set of genomes for comparative analysis

Video Tutorials

Phylogenomics in KBase

Microbial Genomics in KBase - Features and Genes of Interest