# Comparative Genomics & Phylogenetic Analysis KBase’s comparative genomics and phylogenetic analysis [tools](https://kbase.us/applist/#Comparative%20Genomics) enable researchers to understand evolutionary relationships between organisms and explore structural and functional variance across genomes. By integrating public datasets with user data and tools to search for sequence homology, explore gene orthology, and construct phylogenetic linkages between organisms, KBase provides an advanced and useful platform for comparative genomics research. ## Narrative Tutorials * [Build a Gene Tree ](https://narrative.kbase.us/narrative/ws.22290.obj.1)– guides the user through the process of building a gene tree for the "Sulfate Adenylyltransferase" (Sat) gene from Candidatus Desulforudis audaxviator MP104C * [Phylogenomics of Sulfate Reducing Clostridia - Tutorial - Part 1: Comparative Functional Assignment](https://narrative.kbase.us/narrative/ws.18988.obj.1)– guides the user through the process of whole-genome phylogeny, homology, and domain family functional profiling. * [Genome Analysis 2: Identifying Features of Interest in Genomes](https://narrative.kbase.us/narrative/83681) – shows how to build a workflow for searching and identifying features within your genomes * (coming soon) Genome Analysis 3: Domain Annotation and Feature Profiling – guides users through annotating protein families and analyzing features across a set of genomes for comparative analysis ## Video Tutorials {% embed url="" %} Phylogenomics in KBase {% endembed %} {% embed url="" %} Microbial Genomics in KBase - Features and Genes of Interest {% endembed %} --- # Agent Instructions: Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question. Perform an HTTP GET request on the current page URL with the `ask` query parameter: ``` GET https://docs.kbase.us/workflows/comparative-genomics.md?ask= ``` The question should be specific, self-contained, and written in natural language. The response will contain a direct answer to the question and relevant excerpts and sources from the documentation. Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.